• br Declaration of interest br Ethical approval br

  2018-10-25

  

  Declaration of interest Ethical approval Informed consent Acknowledgments The present study was funded by the Institute Of Medical Genetics College Of Life Science, Sichuan University, China. Introduction With the advancement of technologies, laboratory medicine and the need of routi

• hESC NPCs and hfNPCs induced different PBMC proliferative re

  2018-10-24

  

  hESC-NPCs and hfNPCs induced different PBMC proliferative responses, despite relatively similar expression levels of HLA, co-stimulatory and adhesion molecules. Multiple other factors that are produced by NPCs and may contribute to the regulation of the immune response such as inducible nitric oxide

• While i n administered MSCs were clearly detected

  2018-10-24

  

  While i.n-administered MSCs were clearly detected in the lungs of normal mice, and to a greater extent, the inflamed lungs of mice with chronic AAD 48h later, previous studies in murine models of kidney disease (Huuskes et al., 2015; Togel et al., 2008) had shown that these SCR7 could not be detecte

• HLCs maintained in WEM medium

  2018-10-24

  

  HLCs maintained in WEM medium also demonstrated an increase of the metabolic activity of CYP3A family and 3A4 cytochromes, consistent with a more mature phenotype. However, CYP activity showed significant variability from well to well, with CV% above 15%. Investigation for compounds improving hepat

• The pluripotency of MPSII line

  2018-10-24

  

  The pluripotency of MPSII-4.1 line was confirmed by alkaline phosphatase staining (ALP) and by immunocytochemistry staining (ICC) for endogenous NANOG and -CADHERIN (B) after silencing of the exogenous hOKSM construct. The spontaneous differentiation potential of the iPSC line towards the three ge

• The concept of neoblast specialization at wounds

  2018-10-24

  

  The concept of neoblast specialization at wounds is important in understanding planarian regeneration and opens many avenues for future inquiry. For example, how is the neoblast response tailored to the identity of missing tissues? Do specialized neoblasts amplify their population, or do specialized

• Despite PTC characterization as a tumor

  2018-10-24

  

  Despite PTC characterization as a tumor suppressor (Goodrich et al., 1997), we observed that its deletion in astrocyte-like NSCs increases the stemness of these thymidine phosphorylase without promoting tumor formation. Our data are consistent with the results observed upon the noninducible deletio

• Understanding http www apexbt com media diy images wb

  2018-10-24

  

  Understanding the regulatory pathways that control the establishment of the different hematopoietic programs and developing methods to identify and isolate progenitors for each are essential to accurately model hematopoiesis in ESC and induced PSC differentiation cultures and ultimately to generate

• Introduction Glioblastoma multiforme GBM is the most common

  2018-10-24

  

  Introduction Glioblastoma multiforme (GBM) is the most common adult primary eletriptan tumor, with an extremely dismal prognosis and high rate of recurrence following standard therapy (Wen and Kesari, 2008). Populations of brain tumor initiating cells (BTICs), which express many of the properties

• The neurodevelopmental process is orchestrated by a series

  2018-10-24

  

  The neurodevelopmental process is orchestrated by a series of intrinsic mechanisms and extrinsic cues. Among these, intrinsic epigenetic regulation plays an important role in neural progenitor fate specification and provides one explanation about the complexity of developmental processes. DNA methyl

• br Introduction Cardiovascular diseases rank

  2018-10-24

  

  Introduction Cardiovascular diseases rank the first in cause of death, which account for ∼30% of all deaths worldwide (Mozaffarian et al., 2015). Unlike robust cardiac regeneration observed in adult zebrafish and embryonic and neonatal mice (Porrello et al., 2011; Poss et al., 2002; Sturzu et al.

• To further investigate t http www apexbt com media

  2018-10-24

  

  To further investigate the molecular program involved in HEC determination during human hematopoiesis, we generated a GATA2/eGFP reporter in H1 hESCs through gene targeting, referred as GATA2 hESCs. Based on an hPSC blood differentiation protocol in co-culturing with OP9 (Vodyanik et al., 2005), we

• The impairment of cardiac differentiation

  2018-10-24

  

  The impairment of cardiac differentiation resulting from Cited2 depletion at the onset of ESC differentiation may be due to a consequent downregulation of Brachyury and Mesp1 expression. The decrease of Isl1, Nkx2.5, Gata4, and Tbx5 expression that we observed in Cited2-depleted cells at D5 of diffe

• poly ic In addition clinical data indicate a connection

  2018-10-24

  

  In addition, clinical data indicate a connection between tp53 and mitochondrial function. Our data are in agreement with a prior cohort study of patients with Li Fraumeni syndrome (LFS), which is caused by the germline transmission of TP53 mutation (Wang et al., 2013). In this study, both lymphocyte

• br Results br Discussion We demonstrated

  2018-10-24

  

  Results Discussion We demonstrated a significant positive correlation between the susceptibility of hiPSC-CMs to Mox-induced FPD prolongation and QT prolongation in healthy individuals within a certain concentration range. Thus, in vitro assays using hiPSCs derived from healthy individuals may

14993 records 995/1000 page Previous Next First page 上5页 991992993994995 下5页 Last page