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Main Text On behalf of the International Society
2018-10-29
Main Text On behalf of the International Society for Stem Cell Research (ISSCR) and the Stem Cell Reports’ editorial team, we would like to extend a warm welcome to you and present the inaugural issue of our journal, Stem Cell Reports. Stem Cell Reports is the ISSCR’s new journal, a highly visible
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Because Foxd regulates stem cell properties in
2018-10-26
Because Foxd3 regulates stem cell properties in multiple lineages (Liu and Labosky, 2008; Hanna et al., 2002; Mundell et al., 2012; Mundell and Labosky, 2011; Teng et al., 2008; Tompers et al., 2005), Foxd3 target genes must regulate self-renewal, pluripotency, and/or survival of stem cells. Current
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br Introduction Expansion of hematopoietic
2018-10-26
Introduction Expansion of hematopoietic stem cells (HSCs) in vitro using growth factors has been thwarted by findings that there is loss of HSCs during in vitro expansion. In steady-state hematopoiesis, a majority of HSCs remain quiescent; however, in response to 5-fluorouracil (5-FU) treatment,
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ibuprofen msds br In vitro differentiation Media was removed
2018-10-26
In vitro differentiation Media was removed and the cells were washed with PBS. TrypLE was added for 3min. DMEM containing 20% FCS was added to quench the TrypLE. Cells were centrifuged at 300×g for 3min and the cell pellet was resuspended in APEL medium (Stemcell Technologies) containing 10μM Roc
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br Introduction For more than a decade multipotent stem cell
2018-10-26
Introduction For more than a decade, multipotent stem fairly have been extensively studied for various cardiovascular diseases such as heart failure and ischemic cardiomyopathy, which was defined as the “first-generation” cell therapies (Behfar et al., 2014). The “next-generation” cell therapies
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Here we addressed these problems by focusing on
2018-10-26
Here we addressed these problems by focusing on control of the regional identity of PSC-derived neural progenitors and neurons. The developing neural tube is subdivided into distinct regions along the anteroposterior (A-P) and dorsoventral (D-V) axes, and each region produces a specific subtype of n
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nearly br Results br Discussion We have
2018-10-26
Results Discussion We have successfully established a human stem cell model to study the molecular mechanisms underlying MODY5. Our experimental design, which includes a non-family control hiPSC line and three independent hiPSC lines from each of the three subjects in a MODY5 family, is a well
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To address whether the bivalent state requires
2018-10-26
To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus
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br Acknowledgments br Introduction Thermal air convection in
2018-10-26
Acknowledgments Introduction Thermal air convection in closed and tilted rectangular cavities is of interest due to the fact that containers of this type are the elements in a great number of technical devices. Their orientation can change smoothly or stepwise, while the convective flows in th
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Broader understanding of pathways of influence could also in
2018-10-26
Broader understanding of pathways of influence could also inform intervention development. A walking intervention involving the installation of walking route signage and leadership for local walking groups in two low-income neighbourhoods in Ireland had only a marginal effect on physical activity (B
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Among many biosorbents tested fungal biomasses have proved
2018-10-26
Among many biosorbents tested, fungal biomasses have proved to possess excellent metal uptake potential (Kapoor and Viraraghavan, 1995; Arvind et al., 2014). Other microbial biosorbents such as algae have also been extensively studied and others such as spiriruna have been commercialized for heavy m
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Interestingly DBS in the medial or intralaminar thalamus
2018-10-26
Interestingly, DBS in the medial or intralaminar thalamus is being used with great success for the treatment of Tourette׳s syndrome [82,83]. One side effect of intralaminar thalamus DBS for Tourette׳s syndrome is profound fatigue. The parameters of stimulation typically include 24h stimulation at hi
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br Experimental br Results and discussion
2018-10-26
Experimental Results and discussion Conclusion O2 and CO2 gas sensor based on PPy–Cu thin film was fabricated successfully dip-coating technique. The structure and morphology of the PPy–Cu films is confirmed by using XRD, SEM, TGA, FT-IR, techniques. All XRD patterns for PPy–Cu deal with XR
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Introduction The human circulatory system consists
2018-10-26
Introduction The human Pirfenidone consists of the heart and the blood vessels, which together maintain a continuous blood flow throughout the body. The heart is a hollow muscle that can pump blood throughout the body, in normal state it beats about 60–80 times per minute, but during exercise, exc
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To date a variety of surface
2018-10-26
To date, a variety of surface chemistries have been proposed to facilitate the covalent immobilization of biomolecules onto paper, such as divinyl sulfone chemistry, diazonium chemistry or polymer chemistry [12–14]. Among them, long-chain and flexible polysaccharides with multiple functional groups
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