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Due to cell cell interactions high
2019-07-26
Due to cell-cell interactions, high concentrations of LTs can be locally generated in a short period of time during an inflammatory response, thus potentiating LT function. The cellular communication can be mediated between immune cells as well as between immune cells other cell types. Several studi
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In conclusion we developed a new
2019-07-26
In conclusion, we developed a new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model that can be useful for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. In addition, we have shown that the dual CysLT1/2 receptor antagonist ONO-6950 can exert protective effect agai
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Our results implicate a critical role for
2019-07-26
Our results implicate a critical role for CXCR-1 in promoting the migration of colonic tumor cells. Expression of this receptor, but not CXCR-2, increased significantly because of the EMT (Fig. 3). Moreover, although Clone A Decitabine express comparable levels of both IL-8 receptors, only CXCR-1 i
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It has been reported that NMDA receptor hypofunction upregul
2019-07-26
It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several Etoposide regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig. 5). Importantly, the MK
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Although the findings detailed above provide ample evidence
2019-07-26
Although the findings detailed above provide ample evidence that the activity of the CRF1 receptor in the amygdala plays a role in the acute and chronic effects of alcohol exposure, several important areas of investigation remain understudied. The majority of the work on CRF1-alcohol interactions ha
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Introduction The inflammation process involves
2019-07-26
Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases naloxone hydrochloride were responsible for activation of the production of prostaglandin
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A neurotoxic syndrome called Intermediate syndrome
2019-07-26
A neurotoxic syndrome called “Intermediate syndrome” has been described after acute cholinergic crisis, which has been interpreted as the result of pre- and postsynaptic disruptions of neuromuscular transmission (Senanayake and Karalliedde, 1987). Other toxic effects with unknown molecular targets h
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Given the molecular pharmacology and in vitro metabolism dat
2019-07-26
Given the molecular pharmacology and in vitro metabolism data, we proceeded to evaluate the in vivo pharmacokinetics of . Mice (=3) were subsequently administered a subcutaneous dose (5mg/kg) with intermittent plasma collections to measure systemic levels of (). Compound achieved a maximum plasma
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br Conflict of interest br Acknowledgements
2019-07-26
Conflict of interest Acknowledgements This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: 2014/00926-3). Introduction The metacestodes of Taenia solium are the causative agent of cysticercosis, which mainly resides the skeletal muscles and the central n
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br Introduction Mammalian proteases comprise both
2019-07-26
Introduction Mammalian proteases comprise both the peptidases or exopeptidases, which act at the N- or C-terminal positions of polypeptides, and proteinases or endopeptidases, which are capable of cleaving peptide bonds in the central regions of polypeptides. The endopeptidases are classified in
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br Materials and methods br
2019-07-26
Materials and methods Results Discussion Innate immunity plays an essential role in the control and elimination of bacterial infection through production of inflammatory cytokines (Liu et al., 2015). Production of inflammatory cytokines requires the recognition of bacterial pathogen-associa
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ligand gated ion channels The potent estrogen EE induced a d
2019-07-25
The potent ligand gated ion channels EE2 induced a decrease in CYP2C11 activity (reduction in 2α-OH and 16α-OH testosterone) and protein at the 200 ppb dose and in this respect was similar to nonylphenol and genistein. This result agrees qualitatively with the results of Hallstrom et al. (1996) who
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Given its high frequency it is not surprising that
2019-07-25
Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant molar concentration calculator to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only
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br Conclusion br Introduction br CRL E ligases in tumorigene
2019-07-25
Conclusion Introduction CRL4 E3 ligases in tumorigenesis Small molecule-based PROTACs PROTAC: Major biological impacts Acknowledgements The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank th
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The commonly used eDNA stains we evaluated
2019-07-25
The commonly used eDNA stains we evaluated were the intercalating dye propidium iodide, the highly sensitive stain PicoGreen commonly used in DNA quantification, the cyanine monomer SYTOX® Green, and the dye 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO) not only sold as a standard for
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