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N methyl d aspartate NMDA
2019-10-14
N-methyl-d-aspartate (NMDA) receptor antagonists, such as MK-801 and phencyclidine, induce cognitive dysfunction in both mice and humans [18]. In addition, antipsychotic drugs ameliorate MK-801-induced cognitive dysfunction; therefore, the acute application of MK-801 can be used as an animal model o
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Among prostaglandins PG PGD remained the most
2019-10-14
Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depresso
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Future analysis could consider using fixed effects also
2019-10-14
Future analysis could consider using fixed effects also with the level set field, , in order to investigate which covariates explain the classification, a feature of the proposed model that we have not yet investigated. Further, multi-type point patterns may also be analyzed with the proposed model
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ATP binding cassette transporters such as ABCA and ABCG
2019-10-14
ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from antioxidants to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation of liver X receptor
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Our previous high throughput screening HTS
2019-10-14
Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based src inhibitors assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21], [22]
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br Protein protein interactions of LEI L DNase II and
2019-10-14
Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino LED209 pathway substitution in the RSL can led to the inhibition of a totally different prote
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Two primary members of the
2019-10-14
Two primary members of the TRIM family – TRIM5α and TRIM25 – function as antiviral effector and immune regulator, respectively. TRIM5α is one of the best characterized members of the TRIM family (both structurally and functionally) and reported to be an important ubiquitin-mediated regulator of a ma
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br Significance Dysregulation of dopamine homeostasis contri
2019-10-14
Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of 4-DAMP governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitalize on Nurr1
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Supported by the Austrian Science Fund
2019-10-14
Supported by the Austrian Science Fund FWF (grant P22521-B18 to A.H.) and the Austrian National Bank (grant 14263 to A.H.). K.J. was funded by the PhD Program DK-MOLIN (FWF-W1241). Acknowledgements Introduction Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more sev
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Physiological changes induced by CRF are mediated through CR
2019-10-12
Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,
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br Methods Adult male B CRHtklee
2019-10-12
Methods Adult male B6, 129 CRHtklee mice (25–30g at the beginning of the experiments) that were wild-type (CRF1R+/+) and recessive homozygous or knockout (CRF1R−/−) were housed six per cage. Mice were 3–5months old and derived from mating CRF1R+/− breeders (Jackson Laboratory, California). Wild-t
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This paper proposes an acceptance process
2019-10-12
This paper proposes an acceptance process and evaluation criteria, specialized for the dedication of indirect COTS SW as well as direct ones. (Step 1) It first recognizes an indirect COTS SW as a target of dedication, unlike EPRI NP-5652/TR-106439. (Step 2) It then determines the safety category of
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We analyzed whether HaCaT cells treated with PLD
2019-10-12
We analyzed whether HaCaT nucleoside analog treated with PLD can alter the expression of genes involved in DNA damage response. Key DNA damage cues activate the sensory DNA-PK/ATM/ATR kinases, which relay two parallel cascades that ultimately serve to inactivate the Cyclin B-cdc2 complex. The protei
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atp chemical formula mass Introduction Neuropathic pain occu
2019-10-12
Introduction Neuropathic pain occurs in approximately one-third of patients with diabetes and is refractory to currently available analgesic drugs (Abbott et al., 2011). This painful diabetic neuropathy (PDN) is associated with elevated levels of methylglyoxal (MG; a reactive glucose metabolite) an
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Furan analogs and N methylpyrrole analogs had completely
2019-10-12
Furan analogs and N-methylpyrrole analogs had completely different SARs. For example, replacement of the furan-2-sulfonyl moiety of 6 with the furan-3-sulfonyl moiety resulted in 8 with a decreased EP1 Efaproxiral Sodium affinity and an increased antagonist activity, while the corresponding chemica
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