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Autophagy is a dynamic process that primarily involves autop
2020-02-05
Autophagy is a dynamic process that primarily involves autophagosome formatting and lysosomal degradation, and these processes are controlled by autophagy-related genes (Atg) (Klionsky et al., 2012). The related protein SQSTM1/p62 (sequestosome 1) importantly serves as a signalling director in sever
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The repeat sequence TTAGGG of telomere could be directly rec
2020-02-05
The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere 12-O-tetradecanoyl phorbol-13-acetate structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telome
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br Introduction The Epstein Barr virus induced
2020-02-05
Introduction The Epstein–Barr virus induced gene 2 (EBI2 also known as GPR183) is a G protein-coupled seven-transmembrane (7TM) receptor that is predominantly expressed in B and T cells [1,2]. It regulates the trafficking of YO-01027 within lymphoid tissues and is highly important for the genera
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All components of the UPP
2020-02-05
All components of the UPP were predicted to be susceptible to oxidative stress due to the cysteine residues in their active sites [36]. Curcusone D inhibits DUBs but has no significant effect on the action of E1, E2s, E3s, or the proteasome, which indicates that the targets of the ROS induced by cur
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Although many GPCR heteromers have been
2020-02-05
Although many GPCR heteromers have been identified using heterologous cell lines, only very few fit all three criteria. This is mainly due to the difficulties to study these structures in native tissues because of the lack of sensitive and selective tools, not only capable of detecting in vivo evide
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The focus of this review is on the diacylglycerol
2020-02-05
The focus of this review is on the diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) enzymes, DGAT1 and DGAT2, that catalyze the esterification of a fatty acyl moiety to a DAG molecule to produce TAG. These enzymes commit DAG to being stored as TAG rather than being diverted for the synthesis of ph
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Celiac disease occurs in the small intestine due
2020-02-04
Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they
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It is also critical that APC CCDC is inhibited
2020-02-04
It is also critical that APC/CCDC20 is inhibited by MCC during the spindle assembly checkpoint, prior to correct chromosome alignment on the mitotic spindle (Box 1, reviewed in 13, 34). As proposed in [13] and demonstrated in [82], human MCC is a heterotetrameric complex consisting of its own molecu
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ido1 inhibitor aminoisobutyric acid BAIBA is a
2020-02-04
β-aminoisobutyric ido1 inhibitor (BAIBA) is a natural catabolite of the branched-chain amino acid thymine. BAIBA was recently found to reduce inflammation in skeletal muscle via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor (PPAR)δ signaling pathway. BAIBA repor
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br Amygdala microcircuitry and fear learning Recent work has
2020-02-04
Amygdala microcircuitry and fear learning Recent work has begun to dissect functional amygdala circuits that are responsible for the acquisition and expression of fear learning. Ciocchi et al. (2010) identified separable populations of Poly (A) Tailing within the CeAL that have opposite response
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Koumine br Results and Discussion br Conclusion
2020-02-04
Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi
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br Materials and methods br Results
2020-02-04
Materials and methods Results Discussion and conclusion The cardiac hypertrophy model can be established by two methods: drug induction and operation. The drug induction method is simple, while the operation method is closer to the real development of the disease. In this experiment, accord
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This investigation est http www apexbt
2020-02-04
This investigation establishes that there is a genetic difference in the enolase loci that correlates with both vegetative growth and virulence phenotypes. DNA sequence analysis of enolase loci from seven P. larvae strains reveals a single SNP that alters the protein sequence at position 331 (Table
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The discovery of proteases that are active in
2020-02-04
The discovery of proteases that are active in organic solvent media has greatly extended their ability in the synthesis of useful products. Microbial proteases which are able be catalyse in non-aqueous solvents present new expectation in enzyme applications. This kind of enzymes gives a major contri
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To elucidate whether the impact of
2020-02-04
To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer aminolevulinic acid driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and po
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