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CK enzymes belong to a conserved family of serine
2020-08-14
CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, PRT 4165 progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzymes also regulate developmental
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DAMGO br Activatable MRI probes MRI is commonly used
2020-08-13
Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires DAMGO agents to enhance the imaging cont
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br Introduction Biocatalysis can be used to synthesize chira
2020-08-13
Introduction Biocatalysis can be used to synthesize chiral building blocks, such as monomers for polymer materials, and precursors for pharmaceuticals [[1], [2], [3], [4]]. Enzymes are very suitable for catalyzing reactions with high enantioselectivity to obtain chiral products. For instance, alc
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br Hypothesis on DDR protective mode of
2020-08-13
Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci
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Among the CYP enzymes CYP D has been considered a
2020-08-13
Among the CYP450 enzymes, CYP2D has been considered a crucial protein that involves in the metabolism of xenobiotics and drugs (Zanger and Schwab, 2013). Some isoforms of the CYP2D subfamily have been well characterized, such as CYP2D6 due to its clinical importance and CYP2D14 in black cattle (Hama
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Magnified regions of the upregulated proteins
2020-08-13
Magnified regions of the upregulated proteins identified by MALDI-TOF are shown in Fig. 2. The identified proteins were phosphoglycerate kinase, fructose-bisphosphate aldolase class II, alcohol dehydrogenase, phosphoglyceromutase, 6-phosphogluconolactonase, malate dehydrogenase, alkyl hydroperoxide
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To elucidate the potential mechanism underlying osteosarcoma
2020-08-12
To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine growth hormone secretagogue and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were arres
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Among prostaglandins PG PGD remained the
2020-08-12
Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depresso
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Hence what is proposed here is a
2020-08-12
Hence, what is proposed here is a technique highly used in reliability engineering: Software Rejuvenation[4], [21], a technique of proactive fault tolerance in which the system is periodically reboot to clean the memory. In fact, it is well known that most critical SW failures are transient. These m
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br Materials and methods br Results and
2020-08-12
Materials and methods Results and discussion Conclusions The fabrication and characterization of AMCs reinforced with SiC and RHA was done in this study. Following conclusions are drawn from the above study: Conflict of interest Authors\' contributions Introduction Industrialisati
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br Methods br Results br Discussion Skin biopsy and
2020-08-11
Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific how to calculate dilutions organs (Donadio et al., 2005, Donadio et al., 2012a,
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In general graphene nanoplatelets have many useful features
2020-08-11
In general, graphene nanoplatelets have many useful features for the design of multifunctional composite materials, including excellent electrical and thermal conductivities, considerable weight-saving lightness, and high mechanical strength [26]. Moreover, they are characterized by a high specific
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br Results br Discussion In this study we have determined
2020-08-11
Results Discussion In this study, we have determined the pathway by which the 3ʹ end of the nascent leading strand is connected with CMGE after priming, revealing that Pol δ likely plays a crucial role in establishing all continuously synthesized leading strands at eukaryotic replication origi
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Thus DGK active sites remain ill
2020-08-11
Thus, DGK-active sites remain ill-defined and, combined with the lack of crystal structures for mammalian DGKs, have limited our understanding of substrate and inhibitor binding. As a result, current DGK inhibitors consist of compounds with poor specificity within the DGK superfamily (de Chaffoy de
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br Discussion In depression an activation of the
2020-08-11
Discussion In depression, an activation of the inflammation process and production of cytokines (including chemotactic cytokines – chemokines) and their receptors may occur due to the stimulation of the immune system. One of the earliest studied and described cytokines in depression is interleuki
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