• br Experimental Procedures br Acknowledgments br Bisphenol A

  2021-03-23

  

  Experimental Procedures Acknowledgments Bisphenol A (BPA) has been recognized as one of the most potent endocrine disruptors, functioning even at very low doses. Although it is anticipated that chenodeoxycholic acid receptor (ER) would mediate these effects of low-dose BPA, studies revealed

• Herbal products may alter the metabolism of certain drugs an

  2021-03-23

  

  Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 hedgehog inhibitor (CYP). These can bring about an alteration of the pharmacokinetics and pharmacolog

• In another study Nutlin a mediated p

  2021-03-23

  

  In another study, Nutlin-3a-mediated p53 activation induced strong negative impact on NF-κB signaling in LPS-stimulated neutrophils and macrophages [34]. Nutlin-3a limited cellular immune response to LPS, partly by attenuating DNA binding activity of NF-κB and impairing transcription of its target c

• Mother rats acutely treated with

  2021-03-23

  

  Mother rats acutely treated with quinpirole (0.5 and 1.0 mg/kg) decreased the pup exploration time but increased the object exploration, so they showed a significantly lower pup preference ratio. They also showed impaired maternal performance in the home cage, consistent with our previous study (Zha

• br Materials and methods br Results br Discussion Tuberculos

  2021-03-23

  

  Materials and methods Results Discussion Tuberculosis is caused by the mycobacterium M. tuberculosis, a pathogen able to survive in the hostile conditions through sophisticated defence mechanisms. In an attempt to clarify some aspects of the M. tuberculosis defence mechanisms, we have inves

• In contrast DAG phosphorylation to PA

  2021-03-23

  

  In contrast, DAG phosphorylation to PA by diacylglycerol kinases (DGKs) represents a quantitatively minor metabolic pathway, but is generally regarded as a main disposal pathway for “signaling” DAG. PA produced by DGKs is an intermediate of the synthesis of CDP-DAG, cardiolipin and PI. However, PA i

• br Inhibition of DHODH The final products

  2021-03-23

  

  Inhibition of DHODH The final products 7a–n were assessed for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. A procedure adapted from the literature was employed (see Experimental), in which oxidation of DHO to ORO is monitored by following the concomitant reduct

• br Materials and methods br Results br

  2021-03-23

  

  Materials and methods Results Discussion Recently, circRNAs have been found to play important diagnostic or prognostic roles in different tumors. For example, aberrant expression levels of different circRNAs are found in ovarian cancer, lung cancer, renal cancer, gastric cancer and particip

• The mammalian two hybrid results described above were all ob

  2021-03-22

  

  The mammalian two-hybrid results described above were all obtained in 293T cells, and thus the higher RLU observed specific to the hCrm1 fusion could be consistent with human Baicalin having an unknown activator that interacts with hCrm1 HEAT repeat 9A and somehow facilitates Crm1-Rev/RRE function.

• br Introduction The dorsal periaqueductal

  2021-03-22

  

  Introduction The dorsal periaqueductal gray matter (dPAG) is a midbrain site markedly involved in fear/anxiety-evoked responses as well as in nociception (see, for example, Bandler and Carrive, 1988, Deakin and Graeff, 1991, Fardin et al., 1984a, Fardin et al., 1984b, Litvin et al., 2007). Chemic

• Our results show that COX and COX inhibition improve

  2021-03-22

  

  Our results show that COX-1 and COX-2 inhibition improve cognitive performance and decrease the neuronal insult during HH. However, when a neuroinflammatory response was observed, COX-1 inhibition was more effective than COX-2 inhibition at reducing microglial activation and augmenting pro-inflammat

• The nuclear receptor NR superfamily of

  2021-03-22

  

  The nuclear receptor (NR) superfamily of ligand regulated transcription factors has proven to be a rich source of targets for the development of therapeutics for a wide range of human diseases. The NR3B subfamily known as the estrogen-related receptor (ERRα[NR3B1], ERRβ[NR3B2] and ERRγ[NR3B3]) regul

• Notably we demonstrated that EP EP

  2021-03-22

  

  Notably we demonstrated that EP2/EP4 receptor-coupled activation of the cAMP signaling pathway accounted for both up-regulation of COX-2 and down-regulation of LOX, which is consistent with the roles of the cAMP signaling pathway in regulation of COX-2 and LOX by PGE2 in a number of other tissues or

• br Conclusions br Declaration of interest br Acknowledgement

  2021-03-22

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• In pregnancy maternal uterine spiral artery SA

  2021-03-22

  

  In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK Eptifibatide (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and i

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