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br Four active site residues of KSTD are fully conserved
2021-01-19
Four active site residues of Δ1-KSTD1 are fully conserved in Δ1-KSTDs from different species (Supplementary Figure S2). These residues are Tyr-119, Tyr-487, and Gly-491 from the FAD-binding domain and Tyr-318 from the catalytic domain. The structure of the Δ1-KSTD1•ADD complex revealed that the hy
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br Use of recombinant collagen to study DDR collagen interac
2021-01-19
Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to
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Similarly LTD concentration dependently enhanced AQP express
2021-01-18
Similarly, LTD4 concentration-dependently enhanced AQP4 expression in astrocytes (Fig. 3). The LTD4-enhanced AQP4 expression was not affected by pranlukast but inhibited by Bay u9773, a non-selective CysLT1/CysLT2 receptor antagonist [33]. Because no selective CysLT2 receptor antagonists are current
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p kip is a member of
2021-01-18
p27kip1 is a member of the cyclin-dependent kinase (CDK) inhibitor family that acts as a potent tumor suppressor in a variety of human cancers and negatively regulates the transition of cells from the G1 to S phase of the cell cycle, protects against inflammatory injury and promotes epithelial diffe
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Yang et al investigatedPsoralidin a coumestan
2021-01-18
Yang et al. investigatedPsoralidin 39, a coumestan derivative isolated from the seed of Psoralea corylifolia, regarding its effects on IR-induced pulmonary inflammation. Psoralidin 39 inhibited the IR-induced COX- 2 expression and PGE(2) production through regulation of PI3K/Akt and NF-κB pathway. A
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Our results for imidacloprid were unexpected considering
2021-01-18
Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic Cerdulatinib synthesis receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im conce
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A previous study reported that it is
2021-01-18
A previous study reported that it is unlikely that silkworm mounts a general type of immune response to all viruses (Liu et al., 2015). It is not clear whether there is a common pattern of host regulation for silkworm viruses. Spry is a general inhibitor of receptor tyrosine kinases (RTKs), which is
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br Experimental Procedures Further details and an outline
2021-01-18
Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific thymidine phosphorylase inhibitor migrate to the periphery of B
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br Results br Discussion Drug resistance poses the greatest
2021-01-18
Results Discussion Drug resistance poses the greatest hurdle of achieving high efficacy with AADs in cancer patients. AAD-treated cancer patients often encounter intrinsic and evasive drug resistance that diminishes the therapeutic efficacy to only minor survival benefits in most cancer types.
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Secondary and primary studies have considered the decision t
2021-01-18
Secondary and primary studies have considered the decision to select the provider and to select components after the component origin is chosen. Examples of secondary and primary studies outside our scope, but still related to decision-making are listed in Tables 1 and 2. The secondary and primary s
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ERR is constitutively active in the absence of endogenous
2021-01-15
ERRγ is constitutively active in the absence of endogenous ligand. However, several synthetic ligands that can repress or induce ERRγ function by disrupting ERRγ-coactivator interactions have been reported to date. The estrogen receptor modulators diethylstilbestrol (DES) and 4-hydroxytamoxifen (4-O
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The assembly and maturation of invadopodia can be initiated
2021-01-15
The assembly and maturation of invadopodia can be initiated by chemical stimuli such as the epidermal growth factor (EGF), as well as the mechanical signals from extracellular matrix (ECM). Upon binding, EGF activates the EGF receptor (EGFR), which further activates several intracellular signaling p
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br Conclusions Enzyme prodrug therapy mediated by implantabl
2021-01-15
Conclusions Enzyme prodrug therapy mediated by implantable biomaterials combines the benefits offered by the site specific drug delivery techniques and the systemic administration of drugs. From the former, SMEPT inherits the localized mode of drug delivery with lower systemic distribution of the
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The contribution of local ETA and ETB
2021-01-15
The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor an American idol in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several stud
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500-card sandwich Celiac disease occurs in the small intesti
2021-01-15
Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they
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