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br Materials and methods br Results br Discussion Recently i
2021-08-14
Materials and methods Results Discussion Recently it has been found that prostaglandins play an important role in modulating the host immune system [1,3,22,23], and some parasites produce these eicosanoid mediators to survive into their hosts [6,[10], [11], [12],24,25]. The discovery that p
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It is of interest to point out
2021-08-14
It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general Scrambled 10Panx of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 defic
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Progesterone s metabolite THP may
2021-08-14
Progesterone's metabolite, 3α,5α-THP, may also be mediating burying and freezing responses. Results show female Long–Evans rats in behavioral estrous have higher P4 levels in serum, lipid metabolism and hippocampus compared to diestrous female Long–Evans rats. Additionally, ovx female Long–Evans ra
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UVRAG is a mammalian ortholog of yeast
2021-08-14
UVRAG is a mammalian ortholog of yeast Vps38 and a promoter of autophagy [51,60,61]. It forms distinct complexes with BECN1 (mammalian ortholog of yeast Vps30/Atg6) and the class III phosphatidylinositol 3-kinase (whose catalytic subunit [PIK3C3] is the mammalian ortholog of yeast Vps34) and contrib
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br Concluding remarks br Transparency document br Acknowledg
2021-08-14
Concluding remarks Transparency document Acknowledgements Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA033572 (RS). The content is solely the responsibility of the authors and does not neces
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For the current studies we used
2021-08-14
For the current studies, we used the selective Epac agonist 8CPT-AM to directly activate the proteins. We chose this pharmacological approach since it allows a direct activation of Epacs rather than using receptor agonists such as PGE2 which could introduce confounding variables. One potential conce
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br Experimental br Results and discussion br Conclusions The
2021-08-14
Experimental Results and discussion Conclusions The fungus Mucor circinelloides MUT44, previously shown to have ene-reductase activity [11], possesses ten genes coding for putative ene-reductases belonging to the Old Yellow Enzymes family. Since the reduction of CC double bonds is one of th
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br Funding br Disclosure of interest br Acknowledgments br
2021-08-14
Funding Disclosure of interest Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic disease characterized by extensive deposits of the extracellular matrix (ECM) that can impair the architecture and function of the lungs (Cavazza et al., 2010). Imbalance between the prolifer
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Overall the evidence and the results from
2021-08-14
Overall, the evidence and the results from in vivo studies clearly indicate that cyclosporine biotransformation can be induced by dasatinib co-administration through induction of CYP3A expression. However, further studies are needed to explore the role of P-gp modulation in DDIs. Conclusion In v
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Developmental relationships between CD bright
2021-08-14
Developmental relationships between CD56bright and CD56dim NK nuciferine remain unresolved; however, several studies indicate that the former is a precursor of the latter. An NK subset with intermediate features between CD56bright and CD56dim has been identified, corroborating this developmental tr
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br Acknowledgements br Introduction Serum triglyceride conce
2021-08-13
Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within app
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We show that direct contact with MSCs is
2021-08-13
We show that direct contact with MSCs is necessary and sufficient to induce DDR2 upregulation in breast cancer cells. DDR2 expression in MSC is required for collagen deposition and leads to increased DDR2 expression and activation in breast cancer cells. This paracrine-autocrine MSC-cancer cell axis
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Compound was generated using a
2021-08-13
Compound was generated using a literature procedure and required two-step Dess–Martin-periodinane/Pinnick oxidation prior to the methylation of the sulfonamide. Compound () was obtained from the Suzuki coupling of the methyl ester intermediate (en route to acetylcholinesterase inhibitor ). Hydrolysi
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br Materials and methods br
2021-08-13
Materials and methods Acknowledgements We thank Drs. Nathan Sherer (University of Wisconsin-Madison) and Bryan Cullen (Duke University) for generous reagent gifts. The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: HIV-2ROD phage from Dr. Ron
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Similar to Bdnf acute administration of RG did not alter
2021-08-13
Similar to Bdnf4, acute administration of RG108 did not alter gene expression of Gria1 and Hdac2, despite their relevance for the task. Gria1 belongs to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic ion channels receptor (AMPAR) family that is known to be crucial for LTP and the strengthening
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