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cAMP is a key secondary messenger
2021-09-28
cAMP is a key secondary messenger which transduces extracellular signals at glucagon receptors to intracellular effector molecules. cAMP-protein kinase A (PKA) pathway increases the gene expression of enzymes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) whic
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Analysis of the GHSR screening data for inactive library mem
2021-09-28
Analysis of the GHSR screening data for inactive library members indicated that the prolinol-derived secondary amine and α-substituted phenoxyacetamide moieties described in were critical for activity. As a result, we initiated the synthesis of follow-up libraries utilizing the solid-phase chemistry
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Previously we have shown that ghrelin and cannabinoids stimu
2021-09-27
Previously, we have shown that ghrelin and cannabinoids stimulate hypothalamic AMPK activity (Kola et al., 2005). In contrast, both the orexigenic compounds have inhibitory effects on AMPK activity in the liver and visceral fat (Kola et al., 2005). In this study, we were able to reproduce our previo
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Acute lung injury is present
2021-09-27
Acute lung injury is present in sepsis and SIRS and is associated with increased pulmonary levels of proinflammatory cytokines and neutrophil extravasation into the alveolar space [19], [24]. Hauser et al. [25] observed that fragmented mitochondria induced pulmonary inflammation via neutrophil activ
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Over the last decade intense
2021-09-27
Over the last decade, intense efforts have been devoted toward identifying IN inhibitors as potential drugs against HIV. Raltegravir and elvitegravir are integrase strand transfer inhibitors (INSTIs) that have been approved for therapy and dolutegravir is another INSTI that is currently in advanced
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The structures of KDM A
2021-09-27
The structures of KDM4A revealed a Cys-His Zn(II) binding site that is close to the substrate binding spot, which bioinformatic analyses indicated was not present in any other histone demethylase subfamily. Therefore, an alternative method to inhibit the KDM4 family (95) would be to use compounds th
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Conflicting data concerning the involvement of H
2021-09-27
Conflicting data concerning the involvement of H2R on glycaemia has also arisen. Its antagonism was reported to decrease [35], not affect [36], [37] and increase [38], [39] gstp1-1 levels. In comparison, the clinical experience with antipsychotic drugs generated clearer evidence for the involvement
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There were limitations to this study Specifically although r
2021-09-27
There were limitations to this study. Specifically, although rigorously examined for accuracy, the NCDB and SEER databases still suffer from issues with data entry and completeness of the treatment record. Of note, although the data were collected on a modern cohort of patients treated from 2010 to
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Although no data exist on Ptc gene expression
2021-09-27
Although no data exist on Ptc52 gene Gedunin in other plant species, the expression pattern presented in this study shows perceptibly low levels of transcript accumulation in tomato seeds and roots, low levels in the stem, flower and green fruit, and high levels in the leaves. This coincides with th
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br Funding This work was partially supported
2021-09-27
Funding This work was partially supported by the National Institute on Alcohol Abuse and Alcoholism, award R00AA021264, startup funds from the Department of Immunology, Herbert Wertheim College of Medicine, and the Office of Research and Economic Development at FIU, and pilot funds from Dr. Werth
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Cytidine 5-triphosphate In the present study we aimed to inv
2021-09-27
In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA Cytidine 5-triphosphate of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type vs.
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br GSMs Secretase cleavage of APP generates a
2021-09-26
GSMs γ-Secretase cleavage of APP generates a number of Aβ peptides [32], [137]. In most cells Aβ1–37, 38, 39, and 42 are produced at low levels (typically each represents 5–20% of total Aβ detected) and the major species generated is Aβ1–40 (typically over 50% of total Aβ). Other Aβ peptides can
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Galanin mediates its activity by binding
2021-09-26
Galanin mediates its activity by binding to three G-protein coupled receptor subtypes (designated GAL1-GAL3). Since GAL3 mRNA is found mainly in regions of the mesolimbic dopamine system, such as the ventral tegmental area, dorsal raphe nucleus, LC, amygdala, hippocampus, thalamus, hypothalamus, NAc
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Bile acids BAs are detergent like amphipathic molecules synt
2021-09-26
Bile acids (BAs) are detergent-like amphipathic molecules synthesized from cholesterol in the liver, stored in the gallbladder, and released into the intestine after food intake in order to facilitate the the full details of dietary lipids and liposoluble vitamins. BAs travel along the intestine an
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There are multiple docking platforms suitable for use
2021-09-26
There are multiple docking platforms suitable for use with nucleic calcifediol receptors. These include: DOCK v4-6 (UCSF) [[68], [69], [70]], AutoDock (Scripps) [71], AutoDock Vina (Scripps) [72], GOLD (Cambridge Crystallographic Data Centre) [73], Surflex-DOCK (BioPharmics) [74], Glide (Schrӧdinge
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