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WP1066 Contradictory results have been described regarding t
2021-10-25
Contradictory results have been described regarding the role of the Shh pathway during vertebrate skeletal myogenesis. Different studies have shown that Shh can increase or inhibit myoblasts proliferation and terminal muscle differentiation, depending on the experimental model [[1], [2], [3], [4], [
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Isoflurane administration during i t procedures can complica
2021-10-25
Isoflurane administration during i.t. procedures can complicate the interpretation of our results since isoflurane has been shown to have both neuroprotective and neurotoxic effects (Jiang et al., 2017). Isoflurane pretreatment has been implicated as having protective effects in ischemia in animal m
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Several small molecules such as erastin and RSL are reported
2021-10-23
Several small molecules, such as erastin and RSL3, are reported to induce ferroptosis in both normal and cancer diltiazem hcl [21,22]. We confirmed that erastin-induced growth inhibition is an ideal ferroptosis model for cardiomyocytes. The erastin inhibits the growth of H9c2 cells in a Fe-dependen
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As illustrated in among all synthesized compounds biphenyl d
2021-10-23
As illustrated in , among all synthesized compounds, biphenyl derivatives , , , , and with substitutions at the 3-position possessed the best FAAH inhibitory capacity. These 5 compounds demonstrated a good activity against FAAH with IC values in a submicromolar range. Nevertheless, when replacing t
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br STAR Methods br Author Contributions
2021-10-23
STAR★Methods Author Contributions Introduction Hyaluronan, a major constituent of the extracellular matrix (ECM), is produced by hyaluronan synthases (HASs) and degraded by hyaluronidases (HYALs) (Vigetti et al., 2014). Physiologically, hyaluronan exists in a form with a molecular weight of
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CAY10433 Finally worth of mention are few papers that
2021-10-23
Finally, worth of mention are few papers that report on the discovery of HO-2 selective inhibitors. In 2013, starting from the screening of a CAY10433 library, the above-mentioned Canadian research group identified Clemizole (Table 6) as a new hit compound for the development of the first series of
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Introduction Hepatitis C virus HCV is a
2021-10-23
Introduction Hepatitis C virus (HCV) is a small (50–80 nm in size) enveloped RNA virus belonging to the Hepacivirus genus of the Flaviviridae family [1]. The HCV particle consists of a nucleocapsid, which contains the positive single-stranded RNA genome covered by a host cell-derived lipid envelope
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Thus our data demonstrate that polymorphisms of
2021-10-23
Thus, our data demonstrate that polymorphisms of GSTP1-1 differentially mediate activation of Prdx6 peroxidase activity, providing a platform to imply that contingent upon their GSTP genotype, individuals will have significant differences in mounting an antioxidant response, particularly affecting p
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br Methods br Results br Discussion
2021-10-23
Methods Results Discussion Our results show that the DRG and the spinal cord express significant amount of GPR35, a previously orphan Gi protein coupled receptor whose stimulation with zaprinast or with KYNA may reduce inflammatory pain. The receptor is also expressed in primary cultures of
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br Conclusion br Author statement br Acknowledgments br Intr
2021-10-23
Conclusion Author statement Acknowledgments Introduction The hypothalamic-pituitary-gonadal (HPG) axis is an important neurohormone network for vertebrates that regulates their gonadal development and maturation, guarantees their pubertal development and maintains their normal reproducti
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GlyRs are members of the
2021-10-23
GlyRs are members of the superfamily of Cys-loop receptors (CLRs) [3]. They form postsynaptic pentameric receptor complexes of α1 and β subunits anchored via the scaffolding protein gephyrin [4]. GlyRs are composed of several domains with the large N-terminal extracellular domain (ECD) important for
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In this study we find that DH CBD induces analgesic
2021-10-23
In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the carnitine palmitoyltransferase level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once
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br Excitatory amino acid transporter
2021-10-23
Excitatory amino Thiorphan transporter-mediated glutamate transport Early studies detailing the presence of uptake systems capable of transporting glutamate and aspartate into neurons and glia represented a critical step in the overall task of demonstrating that l-glutamate was indeed an endogen
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br Genetic rescue of GluR A dependent spatial
2021-10-23
Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific NESS 0327 of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005). Th
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Fmoc-L-Arg(Aloc)2-OH br Calcium permeability pathway It has
2021-10-23
Calcium permeability pathway It has been demonstrated that physiological shear stress in the circulation causes a reversible increase in Ca2+ permeability [29], [30], [31], [32], [33] and electrophysiological evidence has been recently reported for transient activation of the Ca2+-sensitive K+ ch
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