• A comparison of our results with literature data on

  2022-03-26

  

  A comparison of our results with literature data on the action of pregnane and androstane steroids on the functional activity of NMDAR, GABAAR and GlyR enables us to draw the following conclusions. First, androstane steroids (with no substituents at C-17) at a concentration up to 50 μM do not affect

• On the other hand histone

  2022-03-26

  

  On the other hand, histone deacetylase inhibitors can accelerate inflammation resolution by promoting the externalization of AnxA1, a main ALX/FPR2 agonist, with concomitant inhibition of cytokine gene expression in mouse macrophages [30]. Thus, our present results provide an additional mechanism, i

• br Acute host defense Inflammation the

  2022-03-26

  

  Acute host defense Inflammation, the host response to infection and tissue injury, is crucial for survival and restoration of tissue structure and function. This acute response is mediated and governed by a variety of pro-inflammatory circuits to ensure recognition of invading pathogens, coordina

• In terms of cytotoxicity studies under

  2022-03-26

  

  In terms of cytotoxicity studies under two-dimensional cell culture conditions, only two of the above-mentioned publications with liposomal formulations of tyrosine kinase inhibitors reported viability data as compared to respective free drugs. On the one hand, liposomal gefitinib exerted strongly r

• FFAs are essential nutritional molecules that can also

  2022-03-26

  

  FFAs are essential nutritional molecules that can also modulate numerous cellular functions. Fatty IFN-gamma, murine recombinant derivatives like prostaglandins, leukotrienes lysophosphatidic acid, spinhgosine-1-phosphate and others are well documented to carry out signal transduction via G-protein

• (+)-MK 801 br Introduction The nature of chemotherapies is

  2022-03-26

  

  Introduction The nature of chemotherapies is to relieve the tumor burden of the patients by eliminating cancer (+)-MK 801 via inducing cell death, mostly regulated cell death represented by apoptosis [1,2]. Dozens of anticancer agents including clinically used ones kill cancer cells by promoting

• FBPase deficiency is a very rare inborn error of fructose

  2022-03-26

  

  FBPase deficiency is a very rare inborn error of fructose 490 3 sale of autosomal recessive inheritance. This disorder usually occurs in the first year of life through ketotic hypoglycemia and lactic acidosis triggered by catabolic episodes such as prolonged fasting or febrile infections (Steinmann

• br Conclusions br Conflicts of interest br

  2022-03-26

  

  Conclusions Conflicts of interest Funding The research work was partially supported by National Science Center (Contract Grant Number: UMO-2015/19/B/NZ1/00332). Introduction Frusectose-1, 6-bisphosphatase (FBPase) has long been recognized as a potential therapeutic target for the treatm

• The current lack of effective treatments

  2022-03-26

  

  The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th

• Moreover long term treatment of leukemia

  2022-03-26

  

  Moreover, long term treatment of leukemia cells with imatinib activates AKT, ERK and STAT5 signaling pathway and induce upregulation of EZH2 protein in patients with CML, Ph + ALL and human eosinophilic leukemia cell line (EOL-1 cells) [142]. So, resistance to tyrosine kinase inhibitor (TKI) imatini

• Proteinase K br Materials and methods br

  2022-03-26

  

  Materials and methods Results Discussion In general, we have demonstrated that the CRISPR/dCas9-based system, fused with 2 × PP7 and PCP-EZH2, could stably and precisely methylate the H3K27 at specific locus of C/ebpα to silence gene expression and inhibit adipogenic differentiation in 3T3

• The Jumonji JmjC domain containing KDM family members can

  2022-03-26

  

  The Jumonji (JmjC) domain-containing KDM family members can be clustered into seven subfamilies (KDM2 – KDM8). The KDM2 cluster catalyzes H3K36me2/me1 demethylation; in addition, KDM2B/JHDM1B/FBXL10 has been suggested to catalyze demethylation of H3K4me3 [3]. Cell culture studies support that KDM2 p

• Here we report the kinetics of

  2022-03-26

  

  Here, we report the kinetics of inhibition of the MYST HAT family member KAT8 by MG149, and a calculation of the inhibitory constant Ki of MG149 for KAT8. The inhibition of HATs by MG149 could be correlated to inhibition of histone acetylation in murine PCLS upon MG149 treatment, as determined by a

• Sometime ago we have described diamino

  2022-03-26

  

  Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by NG25 and zymosan. In this work we describe new derivative

• Materials and Methods br Results br Discussion Activation of

  2022-03-25

  

  Materials and Methods Results Discussion Activation of TLRs by damage-associated patterns is a well-recognized trigger for inflammation. TLR ligation results in a large increase in glycolytic metabolism in macrophages and other immune cells,12, 27 and we hypothesized that the glycolytic metab

15403 records 426/1027 page Previous Next First page 上5页 426427428429430 下5页 Last page