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br Materials and methods br Results br Discussion
2022-02-14
Materials and methods Results Discussion In this report, we have analyzed the function of an orphan GPCR, and GPR84, using genetically-deficient mice. The expression of GPR84 in the T and PF 1022A in the spleen prompted us to examine the functional responses of these cells under in vitro a
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ICH induced striatal lesion produced a reduction
2022-02-14
ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino p2y receptor transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischem
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In addition this study also
2022-02-14
In addition, this study also showed no obvious increase in apoptosis but obvious increase in necrosis after WZB117 treatment. The possible reason is that apoptosis is an ATP-utilizing process which is an active and programmed form of cell death. In contrast, necrosis is an uncontrolled or pathologic
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A high fat maternal diet
2022-02-14
A high-fat maternal diet during the pregestation period and extending throughout gestation (including the period of conception) has the propensity of affecting early embryonic development and placentation. Previous investigations have revealed that the preimplantation embryos are generally exposed t
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br Material and methods br Results br Discussion
2022-02-14
Material and methods Results Discussion Functional characterization of naturally occurring GCK mutations in patients with impaired glucose homeostasis has widened our knowledge of the catalytic and regulatory mechanisms of this enzyme [3]. In this work, we have biochemically characterized a
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Multiple mechanisms have been suggested by which glucagon ca
2022-02-14
Multiple mechanisms have been suggested by which glucagon can increase energy expenditure although none have been conclusively proven to be responsible. Both enhanced gluconeogenesis and enhanced protein turnover secondary to hyperglucagonaemia have been suggested as the reason for the increased met
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ae3 CSL is endowed with an intrinsic transcription repressiv
2022-02-14
CSL is endowed with an intrinsic transcription-repressive function, and CAF-effector genes are induced as a consequence of CSL downmodulation (Hu et al., 2012, Procopio et al., 2015), as it can occur upon exposure to pro-carcinogenic stimuli such as UVA or smoke-derived compounds (Menietti et al., 2
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Gap junction channels exhibit different types
2022-02-14
Gap junction channels exhibit different types of gating properties. One alternative mechanism that should be mentioned is loop gating in which the extracellular loop of connexin assumes a configuration to form a narrow pathway for closure of unopposed hemichannels [53] and docked junction channels [
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Materials and methods br Results br
2022-02-12
Materials and methods Results Discussion Since LF is a protease, rapid and direct purification is critical for production of functional rLF. Although previous investigators improved the rLF quality by simplifying purification steps, avoiding formation of inclusion body, decreasing degradation
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br GC C and cGMP of mice
2022-02-12
GC-C and cGMP: of mice and men As is usually the case for many genes, most of the studies that relate to GC-C have to date been carried out in mouse models, or in cell lines derived from human colorectal cancer tissue. What appeared to be a lacuna was any report of a human disorder that resulted
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Thus our data demonstrate that
2022-02-12
Thus, our data demonstrate that polymorphisms of GSTP1-1 differentially mediate activation of Prdx6 peroxidase activity, providing a platform to imply that contingent upon their GSTP genotype, individuals will have significant differences in mounting an antioxidant response, particularly affecting p
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br Conclusion In this report we describe the
2022-02-12
Conclusion In this report, we describe the synthesis and evaluation of oxadiazole-based GSK3 inhibitors. Occupation of the ATP-binding pocket in its entirety led to the identification of several potent and selective compounds. These compounds are characterized by IC50 values in the low nanomolar
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Introduction Gestational diabetes mellitus GDM is one of the
2022-02-12
Introduction Gestational diabetes mellitus (GDM) is one of the most common complications associated with pregnancy [1]. Approximately 7.6% of pregnancies in the United States are complicated by GDM [2,3], which significantly increases the mother's risk of developing type 2 diabetes (T2D) later in l
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In addition analysis of the functional elements in
2022-02-12
In addition, analysis of the functional elements in the GnRH promoter region also identified other transcription factor binding sites, such as those for GATA-1 and Oct-1. However, those sites were not further validated in this study. Nevertheless, it has been reported that transcription factors such
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br Conclusion br Conflict of
2022-02-12
Conclusion Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as Introduction Over the past decade, more than a hundred new biopharmaceutical products have been approved and market
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