• br Introduction The fibroblast growth factor receptor FGFR

  2022-07-05

  

  Introduction The fibroblast growth factor receptor (FGFR) pathway is an important oncogenic driver in malignant cancer. It controls cellular processes such as cell proliferation, differentiation, migration, 89 25 sale progression, metabolism, and survival. In non–small-cell lung cancer, the most

• Tyr phosphorylation of AnxA was

  2022-07-05

  

  Tyr23 phosphorylation of AnxA2 was first reported to be involved in endocytosis, particularly in the internalisation of the insulin receptor [20]. Phosphorylated Tyr23 seems to be necessary for the stable association of AnxA2 with endosomes, and for their early-stage transport [14]. The role of AnxA

• br Histamine H R Many of the

  2022-07-05

  

  Histamine H3R Many of the highlight H3R ligands have been described as suitable pharmacological tools for in vitro or in vivo studies and are designated here. The number of ligands and structural categories is huge, and a number of inclusive reviews of the SAR and properties of H3R ligands have b

• The rationale for developing HDACi as anticancer agents was

  2022-07-04

  

  The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and Neochlorogenic acid arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of

• Molecular modeling of the sGC H NOX domain

  2022-07-04

  

  Molecular modeling of the sGC H-NOX domain has placed the β1-domain Cys, β1-C78 and β1-C122, close to the heme binding pocket; specifically, the β1-C78 is placed diametrically opposite to β1-H105, the residue responsible for coordinating the heme iron [42,43]. β1-C78 is enclosed in a highly Phleomyc

• br Pathophysiology of glaucoma Glaucoma is a group of optic

  2022-07-04

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their TNF-alpha, recombinant human protein in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes

• angiotensin ii causes The isoenzyme hGSTP is an attractive

  2022-07-04

  

  The isoenzyme hGSTP1-1 is an attractive drug target due to its high levels of disease association (target validation) and druggability (target tractability) properties [5,6,[17], [18], [19], [20], [21]]. hGSTP1-1 functions as a homodimer protein [18]. Each monomer has two domains, an α/β domain (N-t

• br Concluding Remarks br Outstanding Questions

  2022-07-04

  

  Concluding Remarks Outstanding Questions Acknowledgments Research on DNA glycosylases in our laboratory is supported by the National Science Foundation (MCB-1517695). A.A.R. and N.P.B. are supported by the National Science Foundation Graduate Research Fellowship Program (DGE-1445197). In

• In contrast to short term effects long

  2022-07-04

  

  In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty hdac inhibitors oxidation cycle [13], decreased NADPH content [14], endoplasmic reticulum (ER)

• Apple juice is the most consumed apple

  2022-07-04

  

  Apple juice is the most consumed apple derivative since more than 20% of freshly harvested apples are consumed as juice (Schulze et al., 2014). Apple juice production implies several technological interventions, among which are skin and pomace removal, enzymatic depectinization, and pasteurization.

• Young et al described the role

  2022-07-04

  

  Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c

• 2-Chlorotrityl Chloride Resin Given the estimated number of

  2022-07-04

  

  Given the estimated number of 150–300 NSVDC channels in a red cell [7] and a single channel conductance of 30 pS at physiological salt concentrations [6], the maximum conductance observed in intact red 2-Chlorotrityl Chloride Resin indicate either a very low open state probability, in the order of

• PF-00562271 receptor Two types of processes intrinsic and

  2022-07-04

  

  Two types of processes, intrinsic and extrinsic, contribute synergistically to the age-related change on structural integrity and physiological function of the skin (Farage, Miller, Elsner, & Maibach, 2008). Intrinsic aging arise from genetically programmed cell aging, normal metabolic activities, a

• WM-8014 br Author contributions br Conflict of interests br

  2022-07-04

  

  Author contributions Conflict of interests Acknowledgements This work was supported by NIH grant DK098730 to NHM. Free fatty acids play important roles in biological processes contributing to both health and disease. As essential nutritional components, free fatty acids are utilized as b

• In patients with breast cancer ZRANB gene amplification

  2022-07-02

  

  In patients with breast cancer, ZRANB1 gene amplification was found in a subset of cases, and ZRANB1 protein levels correlated with EZH2 protein levels and poor survival (both TNBC and non-TNBC). Moreover, unlike normal mammary epithelial cells, all human breast cancer cell lines examined (both TNBC

15814 records 396/1055 page Previous Next First page 上5页 396397398399400 下5页 Last page