• Main Text There are over small GTPases

  2022-07-30

  

  Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, iox synthesis dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-bou

• br Materials and methods br Results br

  2022-07-30

  

  Materials and methods Results Discussion The compound P7C3 has been reported to activate NAMPT (Wang et al., 2014) and augment NAD+ levels, thereby promoting the survival of mature neurons and postnatal neurogenesis throughout the post-ischemic Cytidine 5-triphosphate (Loris et al., 2017).

• Any brain damage including that caused by amyloid

  2022-07-30

  

  Any Carbetocin damage, including that caused by β-amyloid, triggers activation of microglia, the resident immune cells of the CNS. These cells cluster around amyloid plaques, in which they extend cytoplasmic processes (Combs, 2009). The significance of this response is controversial, but one possib

• br Introduction br Mitochondrial dysfunction and cancer

  2022-07-30

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

• To further investigate its role in stresses tolerance

  2022-07-29

  

  To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that Urea level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpression lines (Fig. 1, F

• Another group of secreted proteins that determine

  2022-07-29

  

  Another group of secreted proteins that determine the virulence of V. dahliae are effectors and microbe associated molecular patterns (MAMP) that regulate plant immunity [10]. So far, there is only one DHEA gene Ave1 cloned in V. dahliae, yet it does not exist in race 2 strains such as V592 and sequ

• Lamina II SG spinal cord neurons play an important

  2022-07-29

  

  Lamina II (SG) spinal cord neurons play an important role in regulating nociceptive input from the periphery [20,21]. Moreover, lamina II neurons are concentrated with glycinergic or GABAergic inhibitory interneurons. Therefore, it is possible that β-alanine might modulate nociceptive transmission i

• br Acknowledgements br Introduction Obesity is a

  2022-07-29

  

  Acknowledgements Introduction Obesity is a growing pandemic, which becomes a global public health problem. The evidence has been readily available and mounting, demonstrating that obesity increases incidences of chronic comorbidities, such as non-alcoholic fatty liver diseases, diabetes, cardi

• Bergmann glia cells BGCs are the

  2022-07-29

  

  Bergmann glia thapsigargin (BGCs) are the most abundant glia cells in the cerebellum, comprising more than 90% of the cerebellar glia. These cells span the entire cerebellar molecular layer and encapsulate neuronal somata, dendrites and axons. BGC are involved in neurotransmitter uptake, K+ homeost

• Raltitrexed Although EAAT may not be involved in

  2022-07-29

  

  Although EAAT3 may not be involved in the induction of morphine-induced CPP, our results suggest that other EAATs may play a role in the behavior because riluzole, an EAAT activator (Frizzo et al., 2004, Fumagalli et al., 2008), abolished morphine-induced CPP. Consistent with this suggestion, a few

• br Introduction As is now well known obesity is

  2022-07-29

  

  Introduction As is now well known, obesity is major risk factor for various diseases such as nonalcoholic fatty liver disease, cardiovascular disease, some cancers (McWilliams and Petersen, 2009), type-2 diabetes mellitus (Jakobsen et al., 2007), and hypertension (Aneja et al., 2004), among other

• br Glucocorticosteroid receptor structure and function The g

  2022-07-29

  

  Glucocorticosteroid receptor structure and function The gene encoding for the human GR is composed of 9 exons (Oakley and Cidlowski, 2011) and the translated protein is described as having 4 functional regions. The protein contains a highly conserved central DNA-binding domain (DBD) or C-domain,

• donepezil hydrochloride synthesis Although GLP has greater i

  2022-07-29

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• For many plasma membrane receptors including GPCRs

  2022-07-29

  

  For many plasma membrane receptors including GPCRs, their density on the cell-surface is finely controlled by various transcriptional, post-transcriptional and post-translational mechanisms, and is often a determinant of overall receptor function in a cell. To date, the transcriptional regulation an

• Methods br Results br Discussion SV exocytosis from excitato

  2022-07-29

  

  Methods Results Discussion SV exocytosis from excitatory boutons is more sensitive to inhibition by isoflurane than exocytosis from inhibitory boutons,4, 31 but the mechanism(s) of this synaptic selectivity is unknown. Although P/Q-type VGCCs contributed quantitatively more to SV exocytosis t

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