• In this study using pure

  2023-01-14

  

  In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis a66 with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We present evidence for

• The results of cell culture models were

  2023-01-14

  

  The results of cell culture models were further supported by in vivo studies in mice treated with PXR and/or AhR agonists, PCN and β-NF. In these mice, AhR-regulated cyp1a1, and cyp1a2 were suppressed by PXR activation as determined by real time Q-PCR (Fig. 3). The level of PXR mRNA was not changed

• To date more than different

  2023-01-13

  

  To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su

• The downstream targets of ATR involved in mediating

  2023-01-13

  

  The downstream targets of ATR involved in mediating human telomerase recruitment have not yet been identified. Under stalled fork conditions, activated ATR is able to phosphorylate and activate ATM (Stiff et al., 2006, and Figures 4C and 4D); whether this Fmoc-Val-OH of ATM participates in a positiv

• Natural compounds present in medicinal and

  2023-01-10

  

  Natural compounds, present in medicinal and/or nutritional plants as well as in macrofungi sources, have stimulated a great interest from the pharmaceutical industry. Different natural compounds such as phenolic compounds, alkaloids, terpenoids among others, have shown strong antiangiogenic effects

• There are no studies documented

  2023-01-10

  

  There are no studies documented the role of RAS in the differentiation of MSCs into IPCs but there are previous studies indicating that Ang II receptors exhibit opposing actions on MSCs differentiation, into other cell types rather than IPCs. The blockade of AT2R was reported to suppress MSCs differ

• br Acknowledgments and Disclosures br Introduction Over the

  2023-01-10

  

  Acknowledgments and Disclosures Introduction Over the last decade, the most visible strategy for the treatment of Alzheimer's disease (AD) has been amyloid β peptide (Aβ) immunotherapy (reviewed in [1]). Although the first efforts with Aβ immunotherapy failed to complete clinical trials [1], A

• t-type calcium channel br Conclusion br Conflict of Interest

  2023-01-10

  

  Conclusion Conflict of Interest Author Contributions Acknowledgements This work was supported by a research grant (SR/50/AS-14/2012) from the Department of Science and Technology, New Delhi, India to CMC and CSIR Senior Research Fellowship (09/013(0339)/2010-EMR-I) to SB. Introduction

• We have previously shown that the human gonadotropins hLH

  2023-01-10

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor UO 126 (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight in the

• Since natural and recombinant glycoprotein hormones exhibit

  2023-01-10

  

  Since natural and recombinant glycoprotein hormones exhibit some differences in their carbohydrate structures, we checked whether this could affect the permissive effect on FSK-induced cyclic AMP response in MLTC-1 cells. Fig. 6 shows that the same sensitizing effect to FSK is observed with pituitar

• The following are the supplementary data

  2023-01-10

  

  The following are the supplementary data related to this article. Conflict of interest Acknowledgements Disclosure of interest Introduction Since the introduction of platinum-based chemotherapy, metastatic testicular cancer has become a curable disease and most testicular cancer patien

• A contribution of V ATPase

  2023-01-10

  

  A contribution of V-ATPase subunits specifically to phagosome-lysosome fusion was uncovered by Peri and Nüsslein-Volhard who described that depletion of the VO subunit a1 in zebrafish interferes with phagosome maturation in microglial Ro 61-8048 (Peri and Nusslein-Volhard, 2008). However, loss of th

• The compounds containing beryllium act as strong Lewis

  2023-01-10

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be NS 1619 []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bidentate Be-ba

• Placental cells also express P aromatase CYP A encoded

  2023-01-10

  

  Placental cells also express P450 aromatase (CYP19A1, encoded by CYP19A1). In the placenta, this enzyme requires an external source of androgens, provided by the adrenal gland of the fetus, to form estrogen. The fetal adrenal gland produces dehydroepiandrosterone (DHEA) [9] and, in the placenta, it

• The mechanism governing how mechanotransduction signals

  2023-01-10

  

  The mechanism governing how mechanotransduction signals regulate a number of genes involved in cartilage hemostasis remains unclarified. Mitogen-activated protein kinase (MAPK) pathways are activated by static and dynamic compression of cartilage (31 32). c-Fos/AP-1 is downstream of the MAPK pathway

15762 records 326/1051 page Previous Next First page 上5页 326327328329330 下5页 Last page