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The most ubiquitous serine threonine phosphatases
2022-06-22
The most ubiquitous serine/threonine phosphatases, such as PP1, PP2A, and PP2B are known to contribute to the majority of phosphatase activity in the heart [4]. Dysregulation of these and other PPs have been found in numerous CVDs, including heart failure (HF), and may play a critical role in reduce
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NO has been shown to be
2022-06-22
NO has been shown to be necessary for long-term potentiation (LTP) of GABAergic neurons in the amygdala (Lange et al., 2012), the hippocampus (Zhuo et al., 1993), the ventral tegmental area (VTA) (Nugent et al., 2009), and the spinal cord (Fenselau et al., 2011). NO is also known to increase GABA re
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Fatty acids are also known to activate
2022-06-22
Fatty acids are also known to activate G-protein coupled receptors (GPCRs). LCFAs activate the GPCRs for free fatty lots of people (FFA)1 and FFA4 (Briscoe et al., 2003; Hirasawa et al., 2005), whereas SCFAs activate FFA2 and FFA3 receptors, which are expressed in bovine neutrophils (Alarcon et al.
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br Materials and methods Patients charts were
2022-06-22
Materials and methods Patients’ charts were reviewed retrospectively, and 165 consecutive patients (82 with cancer and 83 without cancer) who either started edoxaban (Lixiana®, Daiichi-Sankyo, Tokyo, Japan) therapy for the treatment of VTE or were switched from other oral anticoagulants to edoxab
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br Introduction Nasopharyngeal carcinoma NPC
2022-06-22
Introduction Nasopharyngeal carcinoma (NPC) is a head and neck epithelial malignancy with high prevalence in southern China, southeast Asia, and northern Africa [1,2]. NPC is caused by a combination of factors: infection with Epstein-Barr virus (EBV), environmental influences, and heredity [3]. A
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The exocytosis promotion is triggered upon the
2022-06-22
The bardoxolone promotion is triggered upon the binding of Ca2+ to the C2 domains of two key protein groups, i.e. complexin and certain synaptogamins (Lai et al., 2017; Rizo and Xu, 2015). The first step of the vesicle fusion is the priming of the secretory vesicles, involved at the switching from
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br Results br Discussion The present findings
2022-06-22
Results Discussion The present findings outline a novel regulatory mechanism for fasting-induced ketogenesis, which involves histamine release from mast LY2801653 sale into the hepatic portal system, H1 receptor-mediated stimulation of liver OEA biosynthesis, and recruitment of the nuclear re
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It has been reported that expression of murine haspin is
2022-06-22
It has been reported that expression of murine haspin is found only in post-meiotic spermatids and that overexpression of murine haspin in HEK-293 cells leads to reduced cell proliferation. Therefore, it was suggested that haspin functions to bring about 4E1RCat arrest in haploid germ cells (Tanaka
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Thus one of the aim of the
2022-06-22
Thus, one of the aim of the work was to link the phytotoxic effect of m-Tyr on root growth of tomato seedlings to modification of RNS level and tissue distribution accompanied by determination of 3-NT content. Due to the role of GSNOR, which is suggested to be a key element in the interplay between
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br Potential endogenous agonists of
2022-06-21
Potential endogenous agonists of GPR35 The first endogenously produced chemical that was shown to be able to activate GPR35 was the tryptophan metabolite kynurenic everything [8]. When human GPR35 was expressed along with a mixture of promiscuous and chimeric G proteins 9, 10 (Box 1) in CHO cell
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The synthesized methoxyamide derivatives were evaluated for
2022-06-21
The synthesized -methoxyamide derivatives were evaluated for in vitro as GPR119 agonists (, , ) whereas GSK1292263 (II in ) was used as the reference standard. To identify novel sulfone or tetrazole surrogates, diverse functional groups including amide, -sulfonyl amide, hydrazide, -methoxy--methyla
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br STAR Methods br Introduction Glycosylation is one of
2022-06-21
STAR★Methods Introduction Glycosylation is one of the most prevalent post-translational modifications of proteins. It not only plays major roles in folding, transport and localization of proteins [1], but also regulates various biological processes such as cell growth, viral replication and im
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To further investigate the molecular
2022-06-21
To further investigate the molecular mechanisms that underlie glycine's β-cell protective effects through its antioxidative activity in diabetes, we used a H2O2/high glucose-induced apoptosis cell model. Similar effects on ROS generation of high glucose and H2O2 support the in vivo results, suggesti
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SGLT inhibitors have been accepted as
2022-06-21
SGLT-2 inhibitors have been accepted as a new class of antidiabetic agent (Kurosaki and Ogasawara, 2013). They limit renal glucose reabsorption and promote urinary excretion of glucose, thereby reducing plasma glucose levels (de Leeuw and de Boer, 2016, Jojima et al., 2016, Pérez López et al., 2010,
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One way to approach this unifying hypothesis will be
2022-06-21
One way to approach this unifying hypothesis will be to compare the effects of the PBR/VDAC ligands on these processes. Recent studies have demonstrated that the three ligands of peripheral-type benzodiazepine receptor, i.e. PK 11195, Ro5-4864 and diazepam reduce membrane transport and conductance i
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