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The Hedgehog Hh pathway is linked to the development
2022-08-10
The Hedgehog (Hh) pathway is linked to the development of several types of epithelial cancers (Rubin and de Sauvage, 2006). A paracrine mechanism has been implicated in CAF activation, with Hh ligands secreted by cancer cells activating the glioma-associated transcription factors (Gli) in surroundin
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br Materials and methods br Results br Discussion Several
2022-08-10
Materials and methods Results Discussion Several peripheral hormones that are involved in the central regulation of energy homeostasis, such as leptin, insulin, and amylin [34], [35], [36], [37], [38], cross the BBB by saturable and unsaturable mechanisms. Whether these transport processes
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Inhibitors of the G rdos effect
2022-08-10
Inhibitors of the Gárdos effect include the Ca2+-channel blocker nitrendipine with an IC50 of ∼103nM (Ellory et al., 1992, Ellory et al., 1992); its mode of action is likely to be from direct blockage of K+ flux through the Gárdos channel (Ellory et al., 1992, Ellory et al., 1992), and the peptidic
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This SAR work led to the identification
2022-08-10
This SAR work led to the identification of compound 10r ((±)-2-[3-fluoro-4-[3-(hexylcarbamoyloxy)phenyl]phenyl]propanoic acid, ARN2508) [51] as a potent in vivo active inhibitor of intracellular FAAH and COX activities, which exerts profound anti-inflammatory effects in mouse models of IBD without c
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MicroRNAs miRNAs are endogenous small RNA molecules nucleoti
2022-08-10
MicroRNAs (miRNAs) are endogenous small RNA molecules 20–25 nucleotides in length; they regulate multiple genes by binding to target mRNAs, thereby controlling the stability and translation of protein coding mRNAs (Esteller, 2011, Guo et al., 2010). It has been established that 623 mg of the innate
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Previous evidence suggests that PRC is an important regulato
2022-08-10
Previous evidence suggests that PRC2 is an important regulator of chromatin looping interactions in embryonic stem asa med . The new study by Donaldson-Collier and colleagues provides the first evidence that similar processes may be at play in lymphoma. It is still largely unclear, however, both in
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Our biological data also showed that in presence
2022-08-09
Our biological data also showed that, in presence of LEDGF/p75, R or S of glycerol T instead of T4, T8 or T12 loop in the T30695-GQ differently affected the integration activity of the enzyme (Table 2), whereas the position but not the chirality of glycerol T affected the inhibitory efficiency of T3
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br New design of an HIF injector Since the
2022-08-09
New design of an HIF injector Since the invention of RFQ, RFQ-based 1 GW HIF plans have been proposed in Japan, Europe and the Soviet Union, such as HIBALL, HIDIF and HIBLIC. In these plans, driver linacs were numerous, huge and complicated. Considering the space-charge-effect of the intense heav
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Toxoplasma gondii is an exceptionally tractable apicomplexan
2022-08-09
Toxoplasma gondii is an exceptionally tractable apicomplexan parasite that expresses a limited yet representative subset of apicomplexan cyclase orthologs, making it an ideal model for investigating cyclic nucleotide signaling in Apicomplexa. Of the five putative nucleotide cyclases, only TgACα1 and
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Further our study provides the
2022-08-09
Further, our study provides the first evidence that zaprinast and kynurenic Gemcitabine HCl administration not only prevented the development of thermal and mechanical hypersensitivity but also enhanced morphine antinociceptive properties. Morphine is considered to be one of the most effective anal
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In addition during the preparation of
2022-08-09
In addition, during the preparation of this manuscript, Oka et al. [7] demonstrated that LPA acts as receptor ligand for GPR35 and that LPA is more potent than KYNA in eliciting a calcium mobilization (EC50: 30nM vs. 39μM for LPA and KYNA, respectively). Other endogenous GPR35 ligands, therefore, mi
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To further investigate its role in stresses tolerance OsGly
2022-08-09
To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that ras pathway level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpression lines (Fi
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These differences have led to the recognition
2022-08-09
These differences have led to the recognition that the extent to which transport contributes to shaping postsynaptic signals likely reflects a balance between the density of transporters and the amount of l-glutamate in the synaptic cleft. Consequently, those synapses exhibiting the characteristics
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Because AM had limited efficacy on rodent GPR we used
2022-08-09
Because (AM-3189) had limited efficacy on rodent GPR40, we used two rodent models expressing human GPR40 to demonstrate efficacy of (AM-3189). First, we used human islet transplanted nude mice. In this model, endogenous pancreatic β-cells were ablated using streptozotocin, and mice were rescued to e
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The transporter was successfully expressed in MSCs and HEK
2022-08-09
The transporter was successfully expressed in MSCs and HEK 293 cells. In both cell types, the expression of YFP-EAAT2 was confirmed by immunological staining and flow cytometry. The functionality of the transporter was determined by [3H]glutamate uptake assays, and the blood glutamate-grabbing activ
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