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Introduction Hepatocellular carcinoma HCC is
2022-09-06
Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, Kifunensine virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4]]. In China, m
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GW was also the starting point for
2022-09-06
GW4064 was also the starting point for a study by an independent research group. The co-crystal structure of GW4064 with FXR suggested the potential for favorable hydrogen bond interactions between the isoxazole 3-aryl group and several receptor residues such as Tyr373 and Ser336. Replacing the 2,6-
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br Conflicts of interest br Funding This work was supported
2022-09-03
Conflicts of interest Funding This work was supported by the National Natural Science Foundation of China (No.81670558; 81800542), and the Science & Technology Development Fund of Tianjin Education Commission for Higher Education (No.2017KJ221). Acknowledgements Introduction Free fatty
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A number of experimental data
2022-09-03
A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in daprodustat australia and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and
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br Material and methods br Results
2022-09-03
Material and methods Results Discussion Accumulating evidence suggests that the hippocampus is sensitive to noise-induced hearing loss and other forms of sensory deprivation, which deprives the hippocampus of sensory information required for its normal operations such as spatial navigation
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Acknowledgments br Introduction Type diabetes mellitus T DM
2022-09-03
Acknowledgments Introduction Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency or insulin resistance in peripheral tissues. The clinical management of T2DM is achieved by controlling blood glucose levels. Current therapies available for treatment of T2DM include biguanides
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The relationship between estrogen and the Hedgehog
2022-09-03
The relationship between estrogen and the Hedgehog pathway as well as the associated mechanism have already been investigated in many tissues, especially in breast cancer (Chang et al., 2012, Katayama et al., 2006, Ramaswamy et al., 2012). Hitherto, even though we have proved that HH-Gli pathway pro
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neurokinin 1 receptor br Materials and methods br Results br
2022-09-03
Materials and methods Results Discussion The global pandemic of T2DM has mandated a search for new types of therapeutic agent and several long-acting analogs of naturally occurring incretins, particularly derivatives of GLP-1, have already been adopted in clinical practice [29]. This study
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FPS-ZM1 The Growth Hormone Secretagogue Receptor
2022-09-03
The Growth Hormone Secretagogue Receptor (GHSR), also known as the ghrelin receptor, is a G protein-coupled receptor (GPCR) expressed widely throughout the body and brain, with particular enrichment in FPS-ZM1 regions concerned with homeostatic and motivational function such as the hypothalamus, hi
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Ellagic acid Sickle erythrocytes are known to have
2022-09-03
Sickle erythrocytes are known to have an increased adhesion to endothelial Ellagic acid (Hebbel et al., 1980, Hebbel et al., 1981a, Hebbel et al., 1981b, Wautier et al., 1985, Mohandas and Evans, 1987). Understanding the events associated with vaso-occlusion requires a detailed knowledge of the int
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FFAs concentration response curves for increasing
2022-09-03
FFAs concentration–response curves for increasing intracellular calcium and receptor phosphorylation showed a difference of ≈1 order of magnitude indicating a relatively large receptor reserve, which is expected for a transfected model, and that high receptor occupancy is necessary to induce recepto
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uPAR promotes cell associated proteolysis
2022-09-03
uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot
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AG-1295 Based on this evidence future
2022-09-03
Based on this evidence, future research should be directed towards the identification of actual receptor oligomeric states at the analyzed cellular surfaces. The macromolecular organization of these oligomeric receptors might establish informational hubs, which relay ligand/receptor interactions in
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Compounds were tested for GPR activity in a functional assay
2022-09-03
Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO RO 4929097 transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the structure activity
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br Acknowledgments br The study was funded by
2022-09-03
Acknowledgments The study was funded by the European Commission FP7-project Beta-JUDO (Grant 279153), and Swedish Diabetes Association (Grant DIA 2013-043) and Family Ernfors Foundation (Grant 150430). Free fatty Sitagliptin phosphate monohydrate receptors (FFARs) represent a family of G-pr
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