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In a study highlighted the usefulness of arginase as a
2024-08-17
In 2010, a study highlighted the usefulness of arginase-1 as a sensitive and specific marker of hepatocytic differentiation for diagnostic pathology [9]. Subsequent studies have validated the high sensitivity and specificity of arginase-1, in particular its added value in evaluating poorly different
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Researchers demonstrated that mitochondria are the main
2024-08-17
Researchers demonstrated that mitochondria are the main producers of ROS and are the most sensitive to the effects of ROS. Mitochondria-mediated apoptosis may not be limited to the role of cytochrome c in the activation of caspase-3 and ROS may provide an alternate mitochondrial signaling pathway (H
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Apelin induced G i activation
2024-08-17
Apelin induced Gαi activation has been demonstrated as a benefiting effect on cardiac contractility [12], [38], [39], and a vasodilator activity that protects against angiotensin-II-induced cardiovascular fibrosis and atheroma [40], [41]. In contrast, stretch causes hypertrophy through diminishing G
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In addition to peroxyl radicals the most found radical forms
2024-08-17
In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as
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br Funding This study was supported by a grant
2024-08-16
Funding This study was supported by a grant from the Science and Technology Program of Guangzhou (No. 2014Y2-00181) and the personnel training program of Southern Medical University (No. PY2015N023). Conflict of interest statement Authors’contributions Introduction Chronic cerebral hypo
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br Results br Discussion Cardiac dysfunction
2024-08-16
Results Discussion Cardiac dysfunction, common complication of severe sepsis, is one cause of death in intensive care units. Accumulated evidence revealed the regulatory effect of autophagy on sepsis-induced cardiac dysfunction [15], [22], although the mechanisms in young and aging are not elu
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Cryptochlorogenic acid synthesis A more versatile cellular d
2024-08-16
A more versatile cellular delivery system for adenosine was generated by engineering mouse embryonic stem cells to lack both Cryptochlorogenic acid synthesis of Adk (Fedele et al., 2004). Using a step-wise differentiation protocol (Okabe et al., 1996) Adk−/− ES cells were differentiated into transp
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luteolin br Actin at presynapses br Conclusion Thanks to the
2024-08-16
Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal luteolin is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these s
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Previous studies have demonstrated ATR inhibition
2024-08-15
Previous studies have demonstrated ATR inhibition is effective for treating cancers combining with chemotherapies in lung adenocarcinoma, gastric cancer, HER2 positive breast cancer and chronic lymphocytic leukemia SP 600125 australia to enhance chemotherapy sensitivity [[16], [17], [18],[20], [21]
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In addition to peroxyl radicals the most found radical forms
2024-08-15
In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as
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br Acknowledgements This work was supported in part
2024-08-15
Acknowledgements This work was supported, in part, by NIH grant R01-GM071760. Introduction The MADS box genes encode a eukaryotic family of transcriptional regulators involved in diverse and important biological functions. This class of proteins has been identified in yeasts, plants, insects,
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The expanding catalog of glutamate receptor
2024-08-15
The expanding catalog of glutamate receptor auxiliary subunits and associated transmembrane proteins underscores the importance and complexity of the receptor complexes. Whereas the interactions described here specifically control AMPARs, distinct auxiliary subunits, Neto-1/2, modulate neuronal kain
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Fig shows a possible scheme of the generation
2024-08-15
Fig. 8 shows a possible scheme of the generation of AP(+)-exosomes based on this study. In response to inflammatory stimuli, ERAP1 is secreted from ER into the extracellular milieu through the conventional secretion pathway. On the other hand, exosomes are derived from the endosomal pathway, and are
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This suggestion was confirmed by immunohistochemical studies
2024-08-15
This suggestion was confirmed by immunohistochemical studies in which the immunoreactivity of the enzyme was actually higher at the earlier rather than at the advanced stages of the disease. Importantly, a later study showed that the biochemical signature of 12/15LO enzymatic activation (i.e., 12-HE
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Em um estudo com modelos de ratinhos
2024-08-15
Em 2011, um estudo com modelos de ratinhos triplamente mutados para hesperetin doença de Alzheimer expôs um grupo a anestesia geral com halotano ou isoflurano cinco horas por semana durante quatro semanas (a três diferentes idades: dois, quatro e seis meses) e um grupo sem exposição aos anestésicos
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