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In order to investigate their effects in vitro therefore we
2024-01-30
In order to investigate their effects in vitro, therefore, we first used TE671 cells, which have provided a useful source of human AChR for in vitro and radioimmunoassay studies. We found no marked effect of either MuSK-MG or SNMG sera on AChR numbers or on AChR subunit expression. This appears to c
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Introduction Microdialysis is an in vivo technique
2024-01-30
Introduction Microdialysis is an in vivo-technique which allows continuous sampling of small molecular weight substances (such as neurotransmitters, metabolites and neuropeptides) from the extracellular space of different tissues or organs, e.g. brain, muscle or skin. While the implantation of the
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Because of its role in tumor
2024-01-30
Because of its role in tumor growth, proliferation and metastasis, Axl is considered a therapeutic target. Several Axl inhibitors, including low-molecular-weight agents and antibodies, have been reported. Axl inhibition, using low-molecular-weight inhibitors or shRNA knockdown, resulted in reduced t
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Young disease transitioning B Sle
2024-01-30
Young disease-transitioning B6·Sle1 mice show partial loss of leukocyte Axl versus B6 controls (data not shown). Further, BMDM from diseased B6·Sle1.Yaa mice do not express detectable levels of ADAM10 and TACE (ADAM17) but do express basal levels of Axl similar to wild type B6-derived BMDM (Suppleme
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V ATPase is a complex enzyme that is composed of
2024-01-30
V-ATPase is a complex enzyme that is composed of several subunits, which are assembled into two domains: trans-membrane (V0) and cytosolic (V1) domains [3,5]. Epididymal epithelial SB-222200 of rats has been reported to contain V-ATPase which is distributed at the apical pole of the narrow and clea
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br ASK in multiple sclerosis and
2024-01-30
ASK1 in multiple sclerosis and optic neuritis Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system (CNS), is the most common neurological disease among young adults in the United States and Europe (Dutta and Trapp, 2011). Although MS primarily affect
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br Materials and methods br Results br
2024-01-30
Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by glucose transport proteins neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated I
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Dopaminergic neurons are vulnerable to oxidative products
2024-01-30
Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial Tanespimycin australia are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dys
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TMC647055 Choline salt Introduction Antimicrobial resistance
2024-01-30
Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of TMC647055 Choline salt [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and
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SRT1720 Negative regulation of AR expression by NF B was
2024-01-30
Negative regulation of AR expression by NFκB was also correlated with the ‘age-dependent desensitisation’ of androgen action in the rat liver (Supakar et al., 1995). In this case the binding site was mapped upstream of the gene to sequences −555 to −565 bp, that binds heterodimers of p65 and p50, as
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br Introduction Hepatocellular carcinoma HCC is the
2024-01-30
Introduction Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related death worldwide and accounts for 70–85% of all liver cancer diagnoses [1]. In East and South-East Asia, the occurrence of HCC and the related number of fatalities have gradually increased in recent decades [2
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These findings suggest that eventually more than one
2024-01-30
These findings suggest that eventually more than one 12/15-lipoxygenase isoform may play a role in human atherosclerosis. Humans have two 12-lipoxygenases and two 15-lipoxygenases which show different expression patterns, substrate specificities and stereo-selective metabolism [1]. However, in GS-93
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To investigate further the clinical and
2024-01-29
To investigate further the clinical and mutational spectrum associated with -related dyskinesia, we here performed a screen in a large series of patients affected with an unexplained hyperkinetic movement disorder, resulting in the identification of 2 pediatric patients presenting with a novel pheno
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adiponectin receptor br Adenosine as a mediator of procedure
2024-01-29
Adenosine as a mediator of procedures used to manage pain The issue of caffeine Caffeine, from dietary sources, is perhaps the most widely consumed behaviorally active agent in the world (Fredholm et al., 1999). Initial characterization indicated caffeine had a higher affinity at A1−, A2A− and
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br There is evidence to suggest
2024-01-29
There is evidence to suggest that GMF activities are regulated in vivo by post-translational modification. indeed, there is strong precedent for ADF-homology family proteins being regulated in this manner. Cofilin is inhibited by phosphorylation of a serine residue at its N terminus. This residue
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