• br Voltage gated sodium channels are essential for modulatin

  2019-05-27

  

  Voltage-gated sodium endothelin receptor are essential for modulating the amplitude and upstroke velocity of the cardiac action potential, which are parameters that are important determinants of impulse propagation and conduction velocity through the myocardium. Functional analyses using patch-cl

• br Methods br Results br Discussion br

  2019-05-27

  

  Methods Results Discussion Conclusions Conflict of interest statement Introduction Pulmonary vein (PV) isolation using a conventional electrode catheter is an effective therapy for atrial fibrillation (AF) [1,2]. However, it requires a long procedure time and has occasionally been

• br Conclusion br Conflict of interest

  2019-05-24

  

  Conclusion Conflict of interest Introduction Dermatofibrosarcoma protuberans (DFSP) is a rare soft-tissue neoplasm that was first identified by Taylor, RW in 1890. It was then described in 1924 by Darier, J and Ferrand, M as a progressive recurrent dermatofibroma, and was later termed DFSP

• To date over mutations in

  2019-05-24

  

  To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [

• br Diarrhoeal diseases are the second most

  2019-05-24

  

  Diarrhoeal diseases are the second most common cause of deaths of children, killing more than 1·5 million children annually and infecting billions more. The recently released Global Action Plan for Pneumonia and Diarrhoea (GAPPD) is a comprehensive strategy document outlining plans to end preventa

• It means an opportunity As we concern

  2019-05-24

  

  It means an opportunity. As we concern ourselves with the prominence of health in the new agenda, it\'s easy to forget that (human) development is by definition people-centred, and that living a long, healthy, and creative life is its cornerstone. The expansion of the new goals to encompass many (if

• Obesity is not the only concern documented

  2019-05-24

  

  Obesity is not the only concern documented for BPA. Epidemiological studies have identified neurocognitive effects of BPA and newly incident coronary artery disease, and laboratory studies strongly suggest BPA is an ovarian toxicant. The rapidly rising evidence of adverse effects has prompted manufa

• br Conclusions br Financial support

  2019-05-24

  

  Conclusions Financial support Conflict of interest Acknowledgment Introduction Cardiac resynchronization therapy (CRT) has been demonstrated to improve symptoms, quality of life, functional status, and reduce mortality and STA-4783 failure-related hospitalizations in patients with Ne

• Las formas literarias de presentaci n

  2019-05-24

  

  Las formas literarias de presentación de los textos aquí comentados son distintas: estamos frente a una obra de teatro, dos artículos (o capítulos de libro) y un cuento. El establecimiento de una ‘periodización’ de la historia de la literatura mexicana a partir de cuatro etapas —la prehispánica,

• adenosine triphosphate Express o territorial desta expans o

  2019-05-24

  

  Expressão territorial desta expansão, no início dos anos 1990 as concessões mineiras ocupavam 2.3 milhões de hectares, enquanto na atualidade, beiram 25 milhões. A atividade deixou de se concentrar nas alturas andinas expandindo‐se para os vales, adenosine triphosphate costa e inclusive a Amazônia.

• diprenorphine Interpretation Haitian children have unaccepta

  2019-05-24

  

  Interpretation Haitian children have unacceptable rates of raised blood lead concentrations, with an unexplained disproportionate elevation in children living in the Centre department. Our findings suggest that routine, widespread screening, detailed investigation into modifiable risk factors, targe

• The Mexico City Policy is also flawed on evidentiary and

  2019-05-24

  

  The Mexico City Policy is also flawed on evidentiary and public health grounds. A 2011 study found that enforcement of the Mexico City Policy by the George W Bush administration led to an increase in abortion rates in sub-Saharan Africa, probably because of decreased contraception access and increa

• Since antithrombotic therapy for patients

  2019-05-23

  

  Since antithrombotic therapy for patients with AF is rapidly changing with the increasing use of dabigatran, rivaroxaban, and apixaban, some of the primary issues that will influence the future revision of various guidelines (HRS [Heart Rhythm Society], ESC [European Society of Cardiology], ACC [Ame

• Numerous clinical trials phase II and phase III have

  2019-05-23

  

  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

• Aggressive osteoblastoma is characterized by epithelioid ost

  2019-05-23

  

  Aggressive osteoblastoma is characterized by epithelioid osteoblasts that are, two to three times larger than conventional osteoblasts, and have abundant eosinophilic cytoplasm, large vesicular eccentric round to oval nuclei with prominent nucleoli. Usually there are rare or absence of mitoses and i

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